Newer medications have been shown to be effective in treating chronic constipation in multi-center, high quality clinical trials. Thsee are prescription medications intended for specific use under a doctor's supervision.

Be sure to take any medication as directed. Always tell your health care professionals about all the medicines you are taking, including over the counter and prescription medicines.

Plecanatide (Trulance) is a drug approved by the US Food and Drug Administration (FDA) in 2017 for treating chronic idiopathic constipation (CIC) in adult patients aged 18 and over. It works by increasing intestinal fluid secretion and muscle movement.

In 2012, linaclotide (Linzess) was approved by the FDA to treat chronic idiopathic (of unknown cause) constipation in adults aged 18 and older. Linaclotide is in a class of medications called guanylate cyclase-C agonists. The oral treatment (capsule) works by increasing the movement of food and waste through the stomach and intestines and by blocking pain signals in the intestines.

Learn more about linaclotide

Lubiprostone (Amitiza) is an oral treatment (capsule) approved by the FDA in 2006. It works by increasing fluid secretion in the small intestine. It helps to ease the passage of the stool. It improves symptoms associated with CIC. 

Working with Your Doctor

patient doctor

Successful relationships with healthcare providers are an important part of managing life with a long-term digestive disorder.

Doctor Visit Worksheet

Tips on Finding a Doctor

How to Talk to Your Doctor